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Enteropathogenic E.coli Induced Diarrhea

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Pathogenic microbes subvert normal host-cell processes to create a specialized niche, which enhances their survival. A common and recurring target of pathogens is the host cell s cytoskeleton, which is utilized by these microbes for purposes that include attachment, entry into cells, movement within and between cells, vacuole formation and remodeling, and avoidance of phagocytosis. One such subversive microbe is a gram-negative pathogen EPEC (Enteropathogenic Escherichia coli) that causes chronic, watery diarrhea in humans, primarily young children and infants. Central to EPEC-mediated disease is its colonization of the intestinal epithelium. After initial adherence, EPEC causes the localized effacement of microvilli and intimately attaches to the host cell surface, forming characteristic A/E (attaching and effacing) lesions. A/E pathogens typically reside on a [...]


1.Diarrheagenic Escherichia coli.
Gomes TA, Elias WP, Scaletsky IC, Guth BE, Rodrigues JF, Piazza RM, Ferreira LC, Martinez MB.
Braz J Microbiol. 2016 Dec;47 Suppl 1:3-30. doi: 10.1016/j.bjm.2016.10.015. Epub 2016 Nov 5. Review.
2.Recent advances in understanding enteric pathogenic Escherichia coli.
Croxen MA, Law RJ, Scholz R, Keeney KM, Wlodarska M, Finlay BB.
Clin Microbiol Rev. 2013 Oct;26(4):822-80. doi: 10.1128/CMR.00022-13. Review.
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