ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

ErbB2-ErbB3 Heterodimers

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

The ERBB (Erythroblastic Leukemia Viral Oncogene Homolog) family of transmembrane RTKs (Receptor Tyrosine Kinases) plays an important role in the pathogenesis of many cancers. This family is comprised of four members EGFR (Epidermal Growth Factor Receptor), ERBB2, ERBB3, and ERBB4, ERBB2 also called HER2 (Heregulin-2) and ERBB3 are closely related to the EGFR/ERBB1, but unlike EGFR, ERBB2 is a ligandless receptor, whereas ERBB3 lacks tyrosine kinase activity. Hence, both ERBB2 and ERBB3 are active only in the context of ERBB heterodimers, and ERBB2-ERBB3 heterodimers, which are driven by NRG (Neuregulin) ligands, are the most prevalent and potent complexes in terms of cell growth and transformation. The basis for the potency of signaling by the ligand-activated ERBB2-ERBB3 heterodimer lies in the [...]

References:

1.Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways.
Wee P, Wang Z.
Cancers (Basel). 2017 May 17; 9(5). pii: E52. doi: 10.3390/cancers9050052. Review.
2.Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation.
Fock V, Plessl K, Draxler P, Otti GR, Fiala C, Knöfler M, Pollheimer J.Fock V, Plessl K, Draxler P, Otti GR, Fiala C, Knöfler M, Pollheimer J.
J Cell Sci. 2015 Dec 1; 128(23):4306-16. doi: 10.1242/jcs.176933. Epub 2015 Oct 21.
You can get all the details on this pathway through subscription