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ErbB4 Pathway

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ERBB4 (Erythroblastic Leukemia Viral Oncogene Homolog-4) is a 180-kDa transmembrane RTK (Receptor Tyrosine Kinase) that regulates cell proliferation and differentiation. The ERBB4 is a member of the EGFR (epidermal growth factor receptor) subfamily of transmembrane RTKs. ERBB4 is expressed in several tissues, mainly heart, mammary gland and the central nervous system. ERBB4 and its ligands have important roles in normal cardiovascular and neural development, differentiation of the mammary gland, and in pathological conditions, such as heart diseases and cancer (Ref.1).

ERBB4 can be activated by at least seven members of EGF-related peptide growth factors: betacellulin, epiregulin, HB-EGF (heparin-binding EGF-like growth factor) and the neuregulins (NRG-1, NRG-2, NRG-3, and NRG-4). Activated ERBB4 forms a homodimer or heterodimerizes with another ERBB family member, [...]


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