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FLT3 Signaling

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FLT3 (Fms-like Tyrosine Kinase-3), also known as FLK2 (Fetal Liver Kinase-2) and STK1 (human Stem Cell Kinase-1) was originally isolated as a hematopoietic progenitor cell-specific kinase, and belongs to the Class-III RTK (Receptor Tyrosine Kinase) family to which c-Fms, c-Kit, and the PDGFR (Platelet Derived Growth Factor Receptor) also belong (Ref.1). Normal expression of FLT3 is restricted to haemopoietic progenitor cells in the bone marrow, thymus and lymph nodes, but is also found on other tissues such as placenta, brain, cerebellum and gonads. Aberrantly expressed FLT3 is observed at high levels in a spectrum of hematologic malignancies including 70% to 100% of AML (Acute Myelogenous Leukemia), B-precursor cell ALL (Acute Lymphoblastic Leukemia), a fraction of T-Cell ALL, and CML (Chronic [...]


1.An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment.
Grafone T, Palmisano M, Nicci C, Storti S.
Oncol Rev. 2012 Apr 17;6(1):e8. doi: 10.4081/oncol.2012.e8. eCollection 2012 Mar 5. Review.
2.High expression of FLT3 is a risk factor in leukemia.
Cheng J, Qu L, Wang J, Cheng L, Wang Y.
Mol Med Rep. 2018 Feb;17(2):2885-2892. doi: 10.3892/mmr.2017.8232. Epub 2017 Dec 8.
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