About Us
Contact Us
Login to Protein Lounge!

Fc-Gamma-RIIB Signaling in B-Cells

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The ability of the immune system to respond appropriately to foreign antigen is dependent on a delicate balance of activating and inhibitory signals. Although positive signaling is essential for the generation of effective immunity, counterbalancing the immune response by inhibitory pathways is equally important. Loss of inhibitory signaling is often associated with autoreactivity and unchecked inflammatory responses, illustrating the essential role these systems play in immune regulation (Ref.1). Pairing of activation and inhibition is therefore, necessary to modulate immune responses. The activation threshold of various cells in the immune system is tuned by immune inhibitory receptors. The inhibitory Fc (Crystalline Fragment) Receptor, Fc-Gamma-RIIB (Fc-Gamma Receptor-IIB), is one of the critical molecules for the regulation of immune responses through antibodies (Ref.2). [...]


1.Suppression of innate and adaptive B cell activation pathways by antibody coengagement of Fc?RIIb and CD19.
Szili D, Cserhalmi M, Bankó Z, Nagy G, Szymkowski DE, Sármay G.
MAbs. 2014 Jul-Aug;6(4):991-9. doi: 10.4161/mabs.28841. Epub 2014 Apr 23.
2.Targeting the Fc receptor in autoimmune disease.
Li X, Kimberly RP.
Expert Opin Ther Targets. 2014 Mar;18(3):335-50. doi: 10.1517/14728222.2014.877891. Review.
You can get all the details on this pathway through subscription