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Fc-GammaR Pathway

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Fcγ receptors are a family of glycoproteins expressed on the membrane of immune cells, and capable of binding the Fc portion of IgG antibody molecules. These receptors bind to various IgG subclasses with different affinities, and when crosslinked by multivalent antigen-antibody complexes, can induce different cellular responses. In humans, several activating receptors (FcγRI/CD64, FcγRIIa/CD32a and FcγRIIIa/CD16a), one inhibitory receptor (FcγRIIb/CD32b), and one glycosylphosphatidylinositol (GPI)-linked receptor, lacking a cytoplasmic tail (FcγRIIIb/CD16b) have been identified [Ref.1].

All activating FcγR containing ITAM sequences signal in a similar way at least at the first signaling step. After crosslinking of activating FcγRs, SRC family kinases, such as FYN, LCK, or LYN, get activated followed by activation of SYK (spleen tyrosine kinase) family kinases. These kinases phosphorylate [...]


1.Fcγ Receptor Heterogeneity in Leukocyte Functional Responses.
Rosales C.
Front Immunol. 2017 Mar 20; 8:280. doi: 10.3389/fimmu.2017.00280. eCollection 2017. Review.
2.Fcγ receptor pathways during active and passive immunization.
Bournazos S, Ravetch JV.
Immunol Rev. 2015 Nov; 268(1):88-103. doi: 10.1111/imr.12343. Review.
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