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Glutathione Metabolism in A. tumefaciens C58 Cereon

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Agrobacterium tumefaciens C58 Cereon is a Gram-negative, non-sporing, motile, rod-shaped bacterium. It is a plant pathogen capable of transferring a defined segment of DNA to a host plant replacing the transferred tumor-inducing genes with exogenous DNA generating a gall tumor. A. tumefaciens strain C58 has an unusual structure consisting of one circular and one linear chromosome (Ref.1 & 2). Glutathione metabolism in A. tumefaciens involves both the synthesis of Glutathione and its catabolism. Glutathione is a small molecule found in almost every cell. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which Glutathione can be made depends on the availability [...]


1.Patterns of bacterial gene movement.
Hao W, Golding GB.
Mol Biol Evol. 2004 Jul;21(7):1294-307.
2.Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.
Goodner B, Hinkle G, Gattung S, Miller N, Blanchard M, Qurollo B, Goldman BS, Cao Y, Askenazi M, Halling C, Mullin L, Houmiel K, Gordon J, Vaudin M, Iartchouk O, Epp A, Liu F, Wollam C, Allinger M, Doughty D, Scott C, Lappas C, Markelz B, Flanagan C, Crowell C, Gurson J, Lomo C, Sear C, Strub G, Cielo C, Slater S.:
Science. 2001 Dec 14; 294(5550):2323-8.
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