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Glutathione Metabolism in L. pneumophila Philadelphia-1

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The genus Legionella represents a wide variety of Gram-negative, aerobic, bacterium that can, under certain circumstances, cause pneumonia, particularly in debilitated individuals. By far the most common species of Legionella responsible for such infections is Legionella pneumophila, considered to be a facultative parasite. L. pneumophila is the causative agent of the Legionnaires disease, a potential fatal pneumonia. The fatality rate for Legionella pneumonia can be as high as 50% in immunocompromised patients, but if diagnosed early, antibiotic therapy commonly results in a successful outcome. In general, among the L. pneumophila clinical isolates, L. pneumophila Philadelphia-1 is the most widely studied that do not display high levels of innate resistance to antibiotics (Ref.1, 2 & 10).

Glutathione in L. pneumophila is a [...]


1.Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.
Cazalet C, Rusniok C, Bruggemann H, Zidane N, Magnier A, Ma L, Tichit M, Jarraud S, Bouchier C, Vandenesch F, Kunst F, Etienne J, Glaser P, Buchrieser C.:
Nat Genet. 2004 Nov; 36(11):1165-73. Epub 2004 Oct 3.
2.Sequence and genome context analysis of a new molecular class D beta-lactamase gene from Legionella pneumophila.
Avison MB, Simm AM.
J Antimicrob Chemother. 2002 Sep; 50(3):331-8.
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