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Glutathione Metabolism in M. tuberculosis H37Rv

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Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine and has numerous important functions within the Mycobacterium cells. Mycobacteria are Gram-positive, non-motile, pleomorphic rods shaped bacteria related to the Actinomyces. Most Mycobacteria are found in habitats such as water or soil. However, a few are intracellular pathogens of animals and humans. M. tuberculosis causes the disease known as tuberculosis. It has the potential to manufacture all of the machinery necessary to synthesize all its essential vitamins, amino acids, and enzyme co-factors. M. [...]


1.Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.
Camus JC, Pryor MJ, Medigue C, Cole ST.
Microbiology. 2002 Oct; 148(Pt 10):2967-73.
2.Is serum gamma glutamyltransferase a marker of oxidative stress?
Lee DH, Blomhoff R, Jacobs DR Jr.
Free Radic Res. 2004 Jun; 38(6):535-9.
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