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Glutathione Metabolism in V. vulnificus YJ016

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Vibrio vulnificus is an etiologic agent for severe human infection acquired through wounds or contaminated seafood. This is a lactose-fermenting, halophilic, Gram-negative, opportunistic pathogen, is found in estuarine environments and is associated with various marine species such as plankton, shellfish (Oysters, Clams, and Crabs), and finfish (Ref.1). V. vulnificus belong to the Gamma-group of Proteobacteria, and it shares morphological and biochemical characteristics with other human Vibrio pathogens, including Vibrio cholerae and Vibrio parahaemolyticus. It is divided into three biotypes according to its different biochemical and biological properties. The genome of Biotype-1 strain, V. vulnificus YJ016, contains two chromosomes (Ref.2).

Glutathione is a tripeptide, composed of glutamate, cysteine and glycine, and has numerous important functions within the bacterial cell. This tripeptide is [...]


1.Pathogenesis of Vibrio vulnificus.
Linkous DA, Oliver JD.
FEMS Microbiol Lett. 1999 May 15; 174(2):207-14
2.Comparative genome analysis of Vibrio vulnificus, a marine pathogen.
Chen CY, Wu KM, Chang YC, Chang CH, Tsai HC, Liao TL, Liu YM, Chen HJ, Shen AB, Li JC, Su TL, Shao CP, Lee CT, Hor LI, Tsai SF.
Genome Res. 2003 Dec; 13(12):2577-87
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