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Glycine, Serine and Threonine Metabolism in M. musculus

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Glycine and Serine are two non-essential neurotrophic amino acids that play an essential role in neuronal development and function in M. musculus (Mus musculus). They share similar neurotrophic effects in promoting neuronal survival and differentiation of sensory ganglia, hippocampal neurons, and cerebellar Purkinje cells. In M. musculus, interplay between Glycine and Serine in a co-existence with L-Threonine represent a major metabolic crossroad that links several other biological pathways of immense importance. L-Serine serves as a building block of proteins, and is of vital importance for the syntheses of L-Cysteine, Phosphatidyl-L-Serine, nucleotides, and the neuromodulators D-Serine and Glycine (Ref.1).

L-Serine is a precursor for the synthesis of membrane lipids, such as Phospholipids and Sphingolipids, and as a result, its demand increases during [...]


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