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Growth Hormone Signaling

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Description

Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old, loss of muscle strength resulting in frailty is the limiting factor for an individual s chances of living an independent life until death. Three hormonal systems show decreasing circulating hormone concentrations during normal aging: (i) estrogen (in menopause) and testosterone (in andropause), (ii) dehydroepiandrosterone and its sulphate (in adrenopause), and (iii) the growth hormone/IGF1 axis (in somatopause). Physical changes during aging have been considered physiologic, but there is evidence that some of these changes are related to this decline in hormonal activity. Science recognizes aging as a disease that can be reversed to a large degree by increasing GH (Growth Hormone) levels where they were in our [...]

References:

1.The role of androgens and estrogens on healthy aging and longevity.
Horstman AM, Dillon EL, Urban RJ, Sheffield-Moore M.
J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1140-52. doi: 10.1093/gerona/gls068. Epub 2012 Mar 26. Review.
2.GH/IGF-1 Signaling and Current Knowledge of Epigenetics; a Review and Considerations on Possible Therapeutic Options.
Alvarez-Nava F, Lanes R.
Int J Mol Sci. 2017 Oct 5;18(10). pii: E1624. doi: 10.3390/ijms18101624. Review.
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