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IGF1R Signaling

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Programmed cell death, a form of altruistic suicide is a genetically controlled means of cellular self-destruction that leads to dismantling and packaging of cell material for removal by phagocytosis. All cells possess the ability to undergo programmed cell death (otherwise known as apoptosis), and the process is essential for normal development to shape organs and tissues as well as to remove damaged cells. Although the cell may require de novo synthesis of some signaling molecules, the machinery for apoptosis is constantly present and may be rapidly activated. Therefore, the process of apoptosis needs tight regulation, and such regulation has been shown to be brought about by signaling through peptide growth factors including the IGF (Insulin-Like Growth Factor) system (Ref.1). The [...]


1.Control of cell survival by IGF signaling pathways.
Vincent AM, Feldman EL.
Growth Horm IGF Res. 2002 Aug; 12(4): 193-7. Review.
2.Role of insulin-like growth factors in neuronal plasticity and neuroprotection.
Torres Aleman I.
Adv Exp Med Biol. 2005;567:243-58.
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