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IL-10 Pathway

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Description

IL-10 (Interleukin-10) is a pleiotropic cytokine with important immunoregulatory functions whose actions influence activities of many of the cell-types in the immune system. It is a cytokine with potent anti- inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-Alpha (Tumor Necrosis Factor-Alpha), IL-6 (Interleukin-6) and IL-1 (Interleukin-1) by activated macrophages (Ref.1). Functional IL-10R (IL-10 Receptor) complexes are tetramers consisting of two ligand-binding subunits (IL- 10R-Alpha or IL-10R1) and two accessory signaling subunits (IL-10R-Beta or IL-10R2). Binding of IL-10 to the extracellular domain of IL-10R1 activates phosphorylation of the receptor-associated, JAK1 (Janus Kinase-1) and TYK2 (Tyrosine Kinase-2), which are constitutively associated with IL-10R1 and IL-10R2, respectively. These kinases then phosphorylate specific tyrosine residues (Y446 and Y496) on the intracellular domain of [...]

References:

1.Expression of the interleukin-10 signaling pathway genes in individuals with Down syndrome and periodontitis.
Cavalcante LB, Tanaka MH, Pires JR, Apponi LH, Aparecida Giro EM, Valentini SR, Palomari Spolidório DM, Capela MV, Rossa C Jr, Scarel-Caminaga RM.
J Periodontol. 2012 Jul;83(7):926-35. doi: 10.1902/jop.2011.110056. Epub 2011 Nov 3.
2.The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.
Huang J, Dibble CC, Matsuzaki M, Manning BD.
Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.
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