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IL-17 Signaling

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Cytokines are key messenger molecules in cell-to-cell communication and are involved in various aspects of the immune system such as maintaining homeostasis and mediating and resolving pathologic conditions. IL-17 (Interleukin-17) family is a group of cytokines sharing homology in amino acid sequences with highly conserved cysteine residues critical to their 3-dimensional shape. IL-17, the signature cytokine secreted by Th17 cells, is required for host defence against extracellular bacterial and fungal infections, and contributes to the pathogenesis of various autoimmune inflammatory diseases. IL-17 has become an important target for treating different forms of inflammatory disorders. Recent clinical trials with agents that target IL-17/IL-17R, the upstream regulation pathways of IL-17 expression and the downstream signaling pathways of IL-17 hold promise for treating [...]


1.Signaling of interleukin-17 family cytokines in immunity and inflammation.
Chang SH, Dong C.
Cell Signal. 2011 Jul;23(7):1069-75.
2.IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential.
Zhu S, Qian Y.
Clin Sci (Lond). 2012 Jun;122(11):487-511.
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