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IL-2 Pathway

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IL-2 (Interleukin-2) is a T-Cell-derived cytokine important in the regulation of growth and differentiation of T-Cells, B-Cells, natural killer cells, glioma cells, and cells of the monocyte lineage after specifically interacting with its receptors. Human IL-2 is a 133-amino acid polypeptide with a molecular mass of 15-18 kDa. IL-2 signaling is mediated by a multichain receptor complex consisting of an alpha (CD25), beta (CD122) and gamma (CD132) chain. The IL-2R (IL-2 Receptor) alpha subunit primarily increases the affinity of ligand binding and is not known to contain a signaling domain, whereas the beta and gamma subunits participate in both ligand binding and signal transduction. The IL-2R signaling system proceeds through at least three different pathways, which mediate the flow of [...]


1.Interleukin-2 receptor signaling: at the interface between tolerance and immunity.
Malek TR, Castro I.
Immunity. 2010 Aug 27;33(2):153-65. doi: 10.1016/j.immuni.2010.08.004. Review.
2.Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.
Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA.
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2788-93. Epub 2006 Feb 13.
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