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IL-3 Pathway

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IL-3 (Interleukin-3) is a cytokine that regulates haemopoiesis, the formation of blood cells in the body. IL-3, also called multi-CSF (multi-lineage colony stimulating factor), is produced by T cells and mast cells, after activation with mitogens or antigens. The molecular weight of IL-3, a protein of 140 amino acids, ranges from 14 to 36 kDa. It stimulates eosinophils and B cell differentiation while it inhibits LAK (Lymphokine-Activated Killer) cell activity. IL-3 shares several biological activities with GM-CSF. IL-3 is capable of inducing the growth and differentiation of multi-potential haematopoetic stem cells, neutrophils, eosinophils, megakaryocytes, macrophages, lymphoid and erythroid cells (Ref.1). IL-3R (IL-3 receptor) is composed of two polypeptide chains, an Alpha subunit of 60-70kDa and a Beta subunit of 130-140kDa. Both subunits contain the extracellular conserved motifs found [...]


1.IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils.
Celestin J, Rotschke O, Falk K, Ramesh N, Jabara H, Strominger J, Geha RS.
J Immunol. 2001 Dec 1;167(11):6097-104.
2.Inhibition of GM-CSF/IL-3/IL-5 signaling by antisense oligodeoxynucleotides targeting the common beta chain of their receptors.
Allam M, Renzi PM.
Antisense Nucleic Acid Drug Dev. 2001 Oct;11(5):289-300.
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