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Integrin Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Adhesive interactions between cells and ECM (Extracellular Matrix) proteins play a vital role in biological processes, including cell survival, growth, differentiation, migration, inflammatory responses, platelet aggregation, tissue repair and tumor invasion and perturbing this coordination can lead to events such as malignant transformation. The major groups of proteins mediating these interactions are a family of cell surface receptors known as Integrins, named for their role in integrating the intracellular cytoskeleton with the ECM (Ref.4). The signals from these adhesion receptors are integrated with those originating from growth factor receptors in order to organize the cytoskeleton, stimulate cell proliferation and rescue cells from matrix detachment and induced programmed cell death (Ref.1). Binding of an alpha, beta1 integrin to its ECM ligand [...]


1.Anoikis molecular pathways and its role in cancer progression.
Paoli P, Giannoni E, Chiarugi P.
Biochim Biophys Acta. 2013 Dec;1833(12):3481-3498. doi: 10.1016/j.bbamcr.2013.06.026. Epub 2013 Jul 2. Review.
2.Integrin and FAK Regulation of Human Pluripotent Stem Cells.
Vitillo L, Kimber SJ.
Curr Stem Cell Rep. 2017;3(4):358-365. doi: 10.1007/s40778-017-0100-x. Epub 2017 Oct 13. Review.
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