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Intracellular Calcium Signaling

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Despite tremendous diversities in their expression, cellular activities in virtually all cell types are regulated by common intracellular signaling systems, and calcium is one important ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation (Ref.1). In response to adequate stimuli, [Ca2+]i (Intracellular Ca2+ concentration) increases, oscillates and decreases, leading to the activation, modulation and termination of cell function. Numerous channels and pumps allow this particular cation to enter and exit cells and move between the cytosol and intracellular stores.

The Ca2+ signaling apparatus includes 1) the RyR (Ryanodine Receptor Channels) that is the SR (Sarcoplasmic Reticulum) Ca2+ release channel, 2) the Troponin protein complex that mediates the Ca2+ effect to [...]


1.Another dimension to calcium signaling: a look at extracellular calcium.
Hofer AM.
J Cell Sci. 2005 Mar 1; 118(Pt 5):855-62
2.Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease.
Berchtold MW, Brinkmeier H, Muntener M.
Physiol Rev. 2000 Jul; 80(3): 1215-65.
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