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Lactose Synthesis

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Lactose (or D-Lactose) is a disaccharide composed of Galactose (or Galactose) and Glucose (or D-Glucose). It occurs only in milk. It is the primary carbohydrate in milk of most species. Lactose is synthesized in mammary glands. Two Glucose molecules are required for each Lactose molecule synthesized. One Glucose is converted to UDP-Glucose (Uridine Diphosphate-Glucose), which in turn is converted to one UDP-Galactose (Uridine Diphosphate-Galactose) by GALE (UDP-Galactose-4-Epimerase) (Ref.1). Another Glucose molecule is used for Lactose synthesis without modification. Glucose passes across the Golgi apparatus membrane into the Golgi apparatus lumen by GLUT1 (Glucose Transporter-1). The presence of GLUT1 on the Golgi apparatus membrane apparently is specific to the mammary epithelial cell, as most cells do not have this GLUT1 on [...]


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