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MAPK Pathways in Budding Yeast

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MAPK (Mitogen-activated protein kinases) are serine-threonine protein kinases that are activated by diverse stimuli ranging from cytokines, growth factors, neurotransmitters, hormones, cellular stress, and cell adherence. MAPKs are expressed in all eukaryotic cells. The basic assembly of MAPK pathways is a three-component module conserved from yeast to humans. The MAPK module includes three kinases that establish a sequential activation pathway comprising a MKKK (MAPK Kinase Kinase), MKK (MAPK Kinase), and MAPK. Yeast probably represents the experimental model where the organization and regulation of MAPK pathways are best understood. Presently, five MAPK pathways have been well characterized in the budding Yeast, Saccharomyces. cerevisiae. The four MAPKs present in vegetative cells, Fus3, Kss1, Hog1, and SLT2/Mpk1, are involved in the mating-pheromone response, [...]


1.Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
Widmann C, Gibson S, Jarpe MB, Johnson GL.
Physiol Rev. 1999 Jan;79(1):143-80.
2.MAP kinase dynamics in response to pheromones in budding yeast.
Van Drogen F, Stucke VM, Jorritsma G, Peter M.
Nat Cell Biol. 2001 Dec;3(12):1051-9.
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