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MAPK Signaling

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MAPKs are a group of protein Serine/threonine Kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. In combination with several other signaling pathways, they can differentially alter phosphorylation status of numerous proteins, including Transcription Factors, Cytoskeletal proteins, Kinases and other Enzymes, and greatly influence Gene Expression, Metabolism, Cell Division, Cell Morphology and Cell Survival. Furthermore, epigenetic aberrations of these enzymes or of the signaling cascades that regulate them have been implicated in a variety of human diseases including Cancer, Inflammation and Cardiovascular disease. There are four major groups of MAPKs in mammalian cells—the ERKs (Extracellular signal-Regulated Kinases), the p38MAPKs, the JNKs (c-Jun NH2-terminal Kinases) and the [...]


1.A network flow-based method to predict anticancer drug sensitivity.
Qin Y, Chen M, Wang H, Zheng X.
PLoS One. 2015 May 18;10(5):e0127380. doi: 10.1371/journal.pone.0127380. eCollection 2015.
2.The role of MAPK in drug-induced kidney injury.
Cassidy H, Radford R, Slyne J, O'Connell S, Slattery C, Ryan MP, McMorrow T.
J Signal Transduct. 2012;2012:463617. doi: 10.1155/2012/463617. Epub 2012 Mar 12.
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