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MDSC Induced Immune Suppression

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MDSCs (Myeloid-Derived Suppressor Cells) are recently been recognized as critical mediators of tumor progression in numerous solid tumours through their inhibition of tumor-specific immune responses. These cells are increased in numerous pathologic conditions, including infections, inflammatory diseases, graft-versus-host disease, traumatic stress, and neoplastic diseases. MDSCs inhibit not only activation of T cells by anti-CD3 and super antigen, but also antigen-specific CD4+ and CD8+ T-cell responses. The mechanisms of MDSC immunosuppression are diverse, it includes up-regulation of ROS (Reactive Oxygen Species), NO (Nitric Oxide), and L-Arginine metabolism. It also facilitates tumour-induced immune suppression and tumour progression by inducing the accumulation of immunosuppressive T-Reg (T regulatory cell) (Ref 1 & 2).

In bone marrow HPC (Hematopoietic Progenitor Cells) proliferate, differentiate, and commit to various hematopoietic [...]


1.Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells.
Serafini P, Mgebroff S, Noonan K, Borrello I.
Cancer Res. 2008 Jul 1;68(13):5439-49
2.Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response.
Sinha P, Clements VK, Bunt SK, Albelda SM, Ostrand-Rosenberg S.
J Immunol. 2007 Jul 15;179(2):977-83.
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