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NGF Pathway

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One of the most fundamental issues in current biology is how to maintain the critical balance between cell survival and death, both during development and in adulthood. Unrestrained cell division and survival leads to various forms of tumor, while excessive or premature cell death may lead to a variety of diseases such as Alzheimer s, Parkinson s and Multiple Sclerosis. In the nervous system, a family of Neurotrophins, which includes NGF (Nerve Growth Factor), BDNF (Brain Derived Neurotrophic Factor), NT3 (Neurotrophin3) and NT4/5 (Neurotrophin-4/5), maintains this critical balance of cell survival and death. The best characterized of these is the NGF, a neurotrophic protein which is important for the growth and survival of diverse peripheral and central neurons. NGF is expressed within [...]


1.Nerve growth factor signaling, neuroprotection, and neural repair.
Sofroniew MV, Howe CL, Mobley WC.
Annu Rev Neurosci. 2001; 24:1217-81. Review.
2.TrkA signalling pathways in human airway smooth muscle cell proliferation.
Freund-Michel V, Bertrand C, Frossard N.
Cell Signal. 2005 Aug 6; [Epub ahead of print]
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