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NGF Pathway

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One of the most fundamental issues in current biology is how to maintain the critical balance between cell survival and death, both during development and in adulthood. Unrestrained cell division and survival leads to various forms of tumor, while excessive or premature cell death may lead to a variety of diseases such as Alzheimer s, Parkinson s and Multiple Sclerosis. In the nervous system, a family of Neurotrophins, which includes NGF (Nerve Growth Factor), BDNF (Brain Derived Neurotrophic Factor), NT3 (Neurotrophin3) and NT4/5 (Neurotrophin-4/5), maintains this critical balance of cell survival and death. The best characterized of these is the NGF, a neurotrophic protein which is important for the growth and survival of diverse peripheral and central neurons. NGF is expressed within [...]


1.Biogenesis and function of the NGF/TrkA signaling endosome.
Marlin MC, Li G.
Int Rev Cell Mol Biol. 2015; 314:239-57. doi: 10.1016/bs.ircmb.2014.10.002. Epub 2014 Nov 18. Review.
2.Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a newplayer.
Uren RT, Turnley AM.
Front Mol Neurosci. 2014 May 14; 7:39. doi: 10.3389/fnmol.2014.00039. eCollection 2014. Review.
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