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NK1R-mediated Non-Apoptotic PCD

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Cell death has been divided into two main types: PCD (Programmed Cell Death), in which the cell plays an active role, and Necrotic (passive) cell death. PCD is a form of cell death in which the cell plays an active role in its own demise. In contrast, Necrosis is characterized by swelling of the cell and its organelles; that results in disruption of the cell membrane and cell lysis. The PCD observed during development and tissue homeostasis has been classified morphologically into three main types: type 1, also known as nuclear or apoptotic; type 2 or Autophagic; and type 3, also referred to as Cytoplasmic. Apoptosis is the best characterized type of PCD, in which the cells display membrane blebbing, [...]


1.A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death.
Castro-Obregon S, Del Rio G, Chen SF, Swanson RA, Frankowski H, Rao RV, Stoka V, Vesce S, Nicholls, DG, Bredesen DE.
Cell Death Differ. 2002 Aug;9(8):807-17.
2.Neurokinin NK1 and NK3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain.
Sanger GJ.
Br J Pharmacol. 2004 Apr;141(8):1303-12. Epub 2004 Mar 15. Review.
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