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OSM Pathway

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Proinflammatory cytokines are the principal intercellular mediators of the tissue reaction to trauma and infection. Members of IL-6 (Interleukin-6) hematopoietic cytokine family, that include IL-6, IL-11, LIF (Leukemia Inhibitor Factor), OSM (Oncostatin M), CNF (Ciliary Neurotrophic Factor), Cardiotrophin-1, and the recently described novel Neurotrophin-1/B-Cell Stimulatory Factor-3 play a particularly prominent role in orchestrating initiation and progression of inflammation, hematopoiesis, acute phase response, bone and heart development as well as neurogenesis. Their redundant effect is attributed to the shared use of the common signal transducing receptor chain GP130 (Glycoprotein-130). GP130 is homodimerized by IL-6 and IL-11 upon binding to their ligand-specific Alpha-receptors. The other cytokines of this family trigger the heterodimerization of GP130 with the LIFR (LIF Receptor) or the OSMR [...]


1.Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor.
Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I.
J Biol Chem. 2000 Dec 29; 275(52): 40742-8.
2.Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor.
Wang Y, Robledo O, Kinzie E, Blanchard F, Richards C, Miyajima A, Baumann H.
J Biol Chem. 2000 Aug 18; 275(33): 25273-85.
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