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Parkinson’s Disease Pathway

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Parkinson s disease is a Neurodegenerative disorder characterized by the progressive loss of Dopaminergic neurons in the substantia nigra and the appearance of intracellular inclusions, named Lewy bodies and Lewy neurites in the remaining nigral neurons. The Substantia nigra is located in the midbrain region of the brain. It consists of two parts: the SNc (pars compacta), and the SNr (pars reticulata). The pars compacta produces dopamine and is the part that degenerates in Parkinson s disease. It is the second most common form of neurodegenerative disease after Alzheimer s, affecting about 1% of people over 65 years old and 4-5% of people over 85 years. Symptoms of Parkinson s disease include a resting tremor, rigidity, bradykinesia, gait dysfunction and postural instability. It is [...]


1.Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causesprogressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.
Lin X, Parisiadou L, Sgobio C, Liu G, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, Lovinger D, Cai H.
J Neurosci. 2012
2.Mitochondrial Dysfunction in Parkinson's Disease.
Moon HE, Paek SH.
Exp Neurobiol. 2015 Jun;24(2):103-16. doi: 10.5607/en.2015.24.2.103. Epub 2015 Jun 8. Review.
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