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Cellular Effects of Sildenafil Cellular Effects of Sildenafil Friday, September 14, 2018
Erectile Dysfunction commonly known as ED or Impotence, affects a large segment of the male population that results in impaired relaxation of the smooth muscle cells in the corpus cavernosum and in the penile arteries. It is an age-related problem that is increasingly common in men aged over 40 years. In the [...]
Cholera Infection Cholera Infection Friday, September 14, 2018
Cholera is one of the most severe diarrheal diseases that affect humans and is responsible for significant morbidity and mortality especially among children in developing countries. It is characterized by numerous, voluminous watery stools, often accompanied by vomiting, and resulting in hypovolemic shock and acidosis. It is caused by certain members of [...]
ATM Pathway ATM Pathway Tuesday, September 11, 2018
ATM (Ataxia Telangiectasia Mutated Protein) belongs to a family of Kinases that have sequence homology to PI3K (Phosphoinositide 3-Kinase).ATM is a key regulator of multiple signaling cascades which respond to DNA strand breaks induced by damaging agents IR (Ionizing Radiation), radiometric agents or by normal processes. These responses involve the activation of [...]
Apoptotic Pathways Triggered By HIV1 Apoptotic Pathways Triggered By HIV1 Tuesday, September 11, 2018
Apoptosis, necroptosis, and pyroptosis are the three major ways of PCD(programed cell death) following virus infection. Among them, apoptosis is the most extensively investigated PCD during viral infection. Apoptosis elicited by virus infection has both negative and positive influence on viral replication.
CCKBR-Gastrin Stimulated Signaling CCKBR-Gastrin Stimulated Signaling Monday, September 10, 2018
Gastrin is the primary hormone that induces gastric acid secretion. In humans, the gene encoding for gastrin is located on chromosome 17q21. This hormone is produced by the G-cells of the antrum of stomach as preprogastrin, which comprises of 101 amino acids and is cleaved between Ala-21 and Ser-22 to yield progastrin.Gastrin [...]
Apoptotic Pathways in Synovial Fibroblasts Apoptotic Pathways in Synovial Fibroblasts Thursday, September 06, 2018
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens.It is characterized by chronic inflammation and synovial hyperplasia that eventually lead to cartilage and bone destruction.
Cardiomyocyte Differentiation through BMP Receptors Cardiomyocyte Differentiation through BMP Receptors Thursday, September 06, 2018
BMP (Bone Morphogenetic Protein) Receptors are essential, beyond the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis. ALK3 (Activin Receptor-Like Kinase-3) is specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum and endocardial cushion. The invariable defects in myocardium results from congenital deletion of [...]
Bacterial Meningitis Bacterial Meningitis Wednesday, September 05, 2018
Bacterial meningitis is an inflammation of the meninges, in particular the arachnoid and the pia mater, associated with the invasion of bacteria into the subarachnoid space.The pathogens take advantage of the specific features of the immune system in the CNS, replicate and induce inflammation. A hallmark of bacterial meningitis is the recruitment [...]