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TNFR2 Pathway TNFR2 Pathway Friday, July 13, 2018
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine with the capacity to induce apoptosis. It is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. TNF is the best studied member of the TNF superfamily. TNF-alpha can bind to two related receptors, TNF receptors 1 [...]
TNFR1 Pathway TNFR1 Pathway Friday, July 13, 2018
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine with the capacity to induce apoptosis. It is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. TNF is the best studied member of the TNF superfamily. TNF-alpha can bind to two related receptors, TNF receptors 1 [...]
TNF Signaling TNF Signaling Friday, July 13, 2018
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine with the capacity to induce apoptosis. It is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. TNF is the best studied member of the TNF superfamily. TNF-alpha can bind to two related receptors, TNF receptors 1 [...]
ERBB Family Pathway ERBB Family Pathway Thursday, July 12, 2018
The ErbB (Erythroblastic Leukemia Viral Oncogene Homolog) or EGF (Epidermal Growth Factor) family of transmembrane RTKs (Receptor Tyrosine Kinases) plays an important role during the growth and development of a number of organs including the heart, the mammary gland, and the central nervous system. In addition, ErbB overexpression is associated with tumorigenesis [...]
P53 Signaling P53 Signaling Thursday, July 12, 2018
p53 is a tumour suppressor protein that regulates the expression of a wide variety of genes involved in Apoptosis, Growth arrest, Inhibition of cell cycle progression, Differentiation and accelerated DNA repair or Senescence in response to Genotoxic or Cellular Stress. As a transcription factor, p53 is composed of an N-terminal Activation Domain, [...]
PPAR Pathway PPAR Pathway Thursday, July 12, 2018
Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPARs (Peroxisome Proliferator-Activated Receptors) are ligand-inducible transcription factors that belong to the nuclear hormone receptor superfamily, together with the receptors for thyroid hormone, retinoids, steroid hormones and vitamin D that act as ligand-activated transcription factors.
PI3K Signaling PI3K Signaling Thursday, July 12, 2018
The (Phosphatidylinositde-3-Kinase) family of enzymes regulate diverse biological functions in every cell type by generating lipid second messengers that ultimately results in the mediation of cellular activities such as proliferation, differentiation, chemotaxis, survival, trafficking and Glucose homeostasis. On the basis of structural similarities, the members are sub-divided into three classes; Class I, [...]
ER-Mediated Phagocytosis ER-Mediated Phagocytosis Thursday, July 12, 2018
Phagocytosis, the process by which cells engulf foreign particles, occurs in eukaryotes ranging from unicellular organisms, which use it for nutrition, to mammals, where it plays a key role in innate immunity. The remarkable phagocytic capacity of Macrophages is illustrated by their ability to internalize particles that can be as large as [...]