TNFR1 Pathway
Tuesday, March 19, 2013
The Tumor Necrosis Factor Receptor (TNFR) super family represents a growing family, with over 20 members having been identified so far in mammalian cells. TNF-Alpha (Tumor Necrosis Factor-Alpha), a potent cytokine, elicits a broad spectrum of biologic responses, which are mediated by binding to a cell surface receptor. TNF has been considered [...]
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TNFR2 Pathway
Tuesday, March 19, 2013
TNF (Tumor Necrosis Factor) family members play important roles in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis, modulation of immune responses and induction of inflammation. TNF acts through two receptors, TNFR1 and TNFR2 (Tumor Necrosis Factor Receptors). TNFR1 is expressed by all human tissues and is the major signaling [...]
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Thalassemia
Friday, February 15, 2013
Thalassemia is one of the most deadly inherited blood disorders, characterized by abnormal production of hemoglobin and excessive destruction of red blood cells. It is a single-gene disorder that is passed from parents to child by autosomal recessive pattern of inheritance. Progressive iron overload and Anemia are the most salient and ultimately [...]
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TNF Signaling
Thursday, February 14, 2013
TNF (Tumor Necrosis Factor) is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. TNF has been considered as an anti-cancer agent since its discovery two decades ago. Members of the TNFR (TNF Receptor) superfamily can send both survival and death signals to cells (Ref.1). TNF [...]
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TH17 Pathway
Thursday, February 14, 2013
T cells acts as a workhorse for the adaptive immune system, with the job of orchestrating defences against microbial invasion. A subcategory of T cells, T helper cells, defends against microbes, also causes trouble by inducing inflammation in immune-mediated diseases. T helper cells become further specialized, or differentiated, and a type known [...]
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miRNA in Cancer
Wednesday, February 13, 2013
Over the last decade, a growing number of non-coding transcripts have been found to have roles in gene regulation and RNA processing. The most well known small non-coding RNAs are the miRNAs/miRs (microRNAs), which have been found to be involved in human tumorigenesis, revealing a new layer in the molecular architecture of [...]
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Antimalaria Drug Mechanism
Wednesday, February 13, 2013
The control of malaria largely depends on drug therapies, and, to a lesser extent, prophylaxis. Most of the antimalarial drugs available currently have been in use for decades, but their use is now severely limited by the emergence and spread of drug resistance, primarily in Plasmodium falciparum, the malaria parasite that causes [...]
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IL-17 Signaling
Tuesday, February 12, 2013
Cytokines are key messenger molecules in cell-to-cell communication and are involved in various aspects of the immune system such as maintaining homeostasis and mediating and resolving pathologic conditions. IL-17 (Interleukin-17) family is a group of cytokines sharing homology in amino acid sequences with highly conserved cysteine residues critical to their 3-dimensional shape
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