About Us
Contact Us
Login to Protein Lounge!

Poliovirus Replication Cycle

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Poliovirus is a member of the Picornaviridae family, which includes a number of significant pathogens of humans (e.g., Rhinoviruses, Coxsackieviruses, Echoviruses, Enteroviruses, and Hepatitis-A virus) and livestock (e.g., foot-and-mouth disease viruses). Poliovirus has three known serotypes: PV1, PV2, and PV3 and all three serotypes can cause poliomyelitis, a paralytic disease resulting from the destruction of motor neurons in the CNS (Central Nervous System). All the three serotypes of Poliovirus recognize a common cellular receptor, CD155 (or PVR, Poliovirus Receptor), for cell attachment and entry. CD155 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The ectodomain of CD155 mediates cell attachment to the ECM (Extracellular Matrix) molecule vitronectin, while its intracellular domain interacts with the dynein light chain. The virus [...]


1.Poliovirus replication and spread in primary neuron cultures
Daley JK, Gechman LA, Skipworth J, Rall GF
Virology. 2005 Sep 15;340(1):10-20.
2.Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis
Mueller S, Cao X, Welker R, Wimmer E.
J Biol Chem. 2002 Mar 8; 277(10):7897-904. Epub 2001 Dec 21.
You can get all the details on this pathway through subscription