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Protein Acetylation and Deacetylation

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Eukaryotic transcription is a highly regulated process, and acetylation plays a major role in this regulation. Acetylation can occur on histones, DNA-binding TF (Transcription Factors), acetylases, nuclear import factors, non-nuclear proteins (Alpha-tubulin) and proteins that shuttle from the nucleus to the cytoplasm, such as the Importin-Alpha family of nuclear import factors. Acetylation can modify the recognition of DNA, the stability of proteins and the interaction between proteins. They regulate different cellular processes, such as microtubule function or nuclear import (Ref.1). By modifying chromatin proteins and transcription-related factors, these acetylases regulate diverse functions, including DNA recognition, protein-protein interaction, protein stability, and transcription of many genes (Ref.2).

Acetylation complexes such as PCAF (p300/CBP-Associated Factor), p300/CBP (CREB Binding Protein), TAFs (TBP-Associated Factors), SRC1 [...]


1.Acetylation: a regulatory modification to rival phosphorylation?
Kouzarides T.
EMBO J. 2000 Mar 15; 19(6): 1176-9. Review.
2.Acetylation of histones and transcription-related factors.
Sterner DE, Berger SL.
Microbiol Mol Biol Rev. 2000 Jun; 64(2): 435-59.
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