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SARS CoV Replication Mechanism

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SARS (Severe Acute Respiratory Syndrome) is a newly emerged infection in humans characterized by fever and pneumonia. This disease may progress rapidly to ARDS (Acute Respiratory Distress Syndrome) with considerable morbidity and mortality. It was first identified in the Guandong Province of China in November 2002, and a major outbreak occurred in Hong Kong in March 2003 (Ref.1). Probable cases have been reported in 31 countries, with extensive ongoing transmission in Taiwan and China, continuing transmission in Hong Kong, and major outbreaks that are now under control in Singapore and Vietnam. There are three different phases of SARS, with symptoms including fever, a dry cough, dyspnea (shortness of breath), headache, and hypoxaemia (low blood oxygen concentration). Typical laboratory findings include [...]


1.A major outbreak of severe acute respiratory syndrome in Hong Kong.
Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC, Chung S, Sung JJ.
N Engl J Med. 2003 May 15; 348(20):1986-94. Epub 2003 Apr 07.
2.SARS coronavirus: a new challenge for prevention and therapy.
Holmes KV
J Clin Invest. 2003 Jun; 111(11): 1605-9. Review. No abstract available.
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