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SOS Repair in E. coli

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All organisms are exposed to a multitude of DNA damaging agents ranging from UV (Ultraviolet) light to fungal metabolites, like Aflatoxin B1. Furthermore, DNA damaging agents, such as ROS (Reactive Oxygen Species), can be produced by cells themselves as metabolic byproducts and intermediates. Together, these agents pose a constant threat to an organism s genome. As a result, organisms have evolved a number of vitally important mechanisms to repair DNA damage in a high fidelity manner. They have also evolved systems (cell cycle checkpoints) that delay the resumption of the cell cycle after DNA damage to allow more time for these accurate processes to occur. If a cell cannot repair DNA damage accurately, a mutagenic event may occur (Ref.1).

Most bacteria, including Escherichia [...]


1.Error-prone repair DNA polymerases in prokaryotes and eukaryotes.
Goodman MF.
Annu Rev Biochem. 2002; 71:17-50. Epub 2001 Nov 09. Review.
2.The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage tolerance.
Sutton MD, Smith BT, Godoy VG, Walker GC.
Annu Rev Genet. 2000; 34:479-497. Review.
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