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STAT3 Mediated Tumor Escape

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Immune cells in the tumour microenvironment not only fail to mount an effective anti-tumour immune response, but also interact intimately with the transformed cells to promote oncogenesis actively. STAT (Signal Transducer and Activator of Transcription) proteins acts as a  mediators of cytokine receptor signaling . This  proteins plays a role in transmitting the signals of growth factor receptors and are both cytoplasmic signaling molecules and nuclear transcription factors that activate diverse genes . In normal cells, STAT activation is transient and tightly regulated . While STAT3 Signal Transducer And Activator Of Transcription 3)   acts as  a point of convergence for numerous oncogenic signalling pathways, and constitutively remain active both in tumour cells and in immune cells in the tumour microenvironment. Constitutively activated STAT3 inhibits [...]


1.Targeting STAT3 affects melanoma on multiple fronts.
Kortylewski M, Jove R, Yu H.
Cancer Metastasis Rev. 2005 Jun;24(2):315-27.
2.Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.
Yu H, Kortylewski M, Pardoll D.
Nat Rev Immunol. 2007 Jan;7(1):41-51.
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