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Structure of Plasmodium Merozoite

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The Plasmodium Merozoite is an ovoid cell and measures approximately 1.5 micron in length and 1 micron in width. The apical end of the Merozoite is a truncated cone-shaped projection demarcated by the polar rings. At the anterior end of the Merozoite are present three types of membrane-bound organelles, namely, Rhoptries (two prominent pear-shaped, 570 X330 nm), micronemes (ovoid bodies, 100 X40 nm), and dense granules (spheroid vesicles, 140 X120 nm). The contents of these organelles play a role in the binding and entry of the Merozoite into the host cells. Extracellular Merozoites are intrinsically short-lived and must rapidly invade a new host erythrocyte (Ref.1). The Merozoite is surrounded by a trilaminar pellicle that is composed of a plasma membrane [...]


1.Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion.
Keizer DW, Miles LA, Li F, Nair M, Anders RF, Coley AM, Foley M, Norton RS.
Biochemistry. 2003 Aug 26;42(33):9915-23.
2.Antigenic cross-reactivity between different alleles of the Plasmodium falciparum merozoite surface protein 2.
Felger I, Steiger S, Hatz C, Smith T, Beck HP.
Parasite Immunol. 2003 Nov-Dec;25(11-12):531-43.
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