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Structure of Plasmodium Trophozoite

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In the life cycle of Plasmodium spp, Erythrocytic stage is very important involving four stages viz. Merozoite stage, ring stage, Trophozoite stage and Schizont stage. On being released from the hepatocytes, the Merozoites enter the bloodstream prior to infecting red blood cells. They use the Apicomplexan invasion organelles to recognize and enter the host erythrocyte. The parasite first binds to the erythrocyte in a random orientation. It then reorients such that the apical complex is in proximity to the erythrocyte membrane. A tight junction is formed between the parasite and erythrocyte. As it enters the red blood cell, the parasite forms a parasitophorous vesicle, to allow for its development inside the erythrocyte. After invading the erythrocyte, the parasite loses its [...]


1.Hemoglobin degradation in malaria-infected erythrocytes determined from live cell magnetophoresis.
Moore LR, Fujioka H, Williams PS, Chalmers JJ, Grimberg B, Zimmerman PA, Zborowski M.
FASEB J. 2006 Apr;20(6):747-9.
2.Recent advances in understanding the mechanism of hemozoin (malaria pigment)formation.
Egan TJ.
J Inorg Biochem. 2008 May-Jun;102(5-6):1288-99.
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