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Synthesis of Cardiolipin and Phosphatidylinositol

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Phosphoglycerides such as phosphatidylethanolamine and phosphatidylserine are the major component of lipid bilayer membranes in which their detergent-like properties help to provide membranes the quality of self-assembly. Phosphatidylglycerol is a precursor in the synthesis of both cardiolipin and PI (Phosphatidylinositol). Cardiolipin is a unique dimeric phospholipid found in the heart and most mammalian tissues. This phospholipid is the only phospholipid localized primarily in the mitochondrial membrane of mammalian cells. In cardiolipin, two phosphatidylglycerol units are joined together. Phosphatidic acid is activated to CDP-DAG (CDP-Diacylglycerol), which is the precursor to PI and cardiolipin. PI is the precursor of PI Phosphates, which have one of more phosphates on the inositol. Hydrolysis of various phosphorylated PI produces DAG and phosphorylated inositides that are [...]


1.A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse.
Cao J, Liu Y, Lockwood J, Burn P, Shi Y.
J Biol Chem. 2004 Jul 23; 279(30):31727-34. Epub 2004 May 19.
2.The biosynthesis and functional role of cardiolipin.
Schlame M, Rua D, Greenberg ML.
Prog Lipid Res. 2000 May; 39(3):257-88. Review.
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