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T-Cell Receptor and CD3 Complex

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The lymphocyte population is mainly made up of the T-lymphocytes (Thymus-Derived Lymphocytes), B-lymphocytes (bone-marrow-derived), and the NK cells (Natural-Killer Cells). T-lymphocytes mediating the cellular immunity, along with B lymphocytes mediating humoral immunity, provide adaptive immunity, which work in close collaboration with the innate immune system. B-lymphocytes mature in the bone marrow itself, while the T-lymphocytes require the thymus to mature, before being deployed to the peripheral lymphoid organs for further antigen-mediated differentiation. These cells are responsible for antibody production, direct cell-mediated killing of virus-infected and tumor cells, and regulation of the immune response (Ref.1).

T cells are key mediators of the adaptive immune response. Each T cell contains a unique TCR (T-cell receptor), which binds antigens displayed by MHCs (Major Histocompatibility [...]


1.CD4⁺T cells: differentiation and functions.
Luckheeram RV, Zhou R, Verma AD, Xia B.
Clin Dev Immunol. 2012; 2012:925135. doi: 10.1155/2012/925135. Epub 2012 Mar 14. Review
2.Molecular architecture of the αβ T cell receptor-CD3 complex.
2. Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC.
Proc Natl Acad Sci U S A. 2014 Dec 9; 111(49):17576-81. doi: 10.1073/pnas.1420936111. Epub 2014 Nov 24.
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