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TREM1 Pathway

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TREMs (Triggering Receptor Expressed on Myeloid Cells) are a family of recently discovered receptors of the immunoglobulin superfamily, expressed on various cells of the myeloid lineage, which play important roles in innate immune responses, such as to activate inflammatory responses and to contribute to septic shock in response to microbial-mediated infections (Ref.1). During the onset of an infection, the host must launch a rapid innate response to control pathogen proliferation and spread the same until the adaptive response of specific T- and B-Cells has fully developed. This first line of defence is provided by the coordinate action of several effector cell types, including the phagocytes. These cells express a large array of cell-surface receptors, some of which detect pathogens and [...]


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