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The Salvage Pathway from Serine to Phosphatidylcholine

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Phosphatidylserine (or 1, 2-Diacyl-sn-Glycero-3-Phospho-L-Serine) is the only amino acid-containing glycerophospholipid in animal cells. Although it is distributed widely among animals, plants and microorganisms, it is usually less than 10% of the total phospholipids, the greatest concentration being in myelin from brain tissue. It is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form.

In bacteria and other prokaryotic organisms, Phosphatidylserine is synthesized by a mechanism comparable to that of other phospholipids, i.e. by reaction of L-Serine with CDP-DAG (CDP-Diacylglycerol).In contrast in animal tissues, there are two routes to Phosphatidylserine involving distinct enzymes: PS Synthase (Phosphatidylserine-I and II), and Phosphatidylserine [...]


1.Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism.
Vance JE.
Prog Nucleic Acid Res Mol Biol. 2003; 75:69-111. Review.
2.Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells.
Kuge O, Nishijima M.
J Biochem (Tokyo). 2003 Apr; 133(4):397-403. Review.
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