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Type-1 Diabetes Mellitus

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Description

Type 1 diabetes, formerly termed IDDM (Insulin-Dependent Diabetes Mellitus), is a chronic organ-specific autoimmune disorder caused by proinflammatory autoreactive CD4+ and CD8+ T cells, which mediate progressive and selective damage of insulin producing pancreatic beta-cells. The reduction of beta-cell mass leads to a lack of insulin and thereby loss of blood glucose control. To date, it has not been possible to prevent the autoimmune response to beta-cells in human, due probably to its unknown aetiology, although it is known that development of T1D is genetically controlled and thought to be initiated in susceptible individuals by environmental factors such as virus infections (Ref.1 & 2).

Epidemiological studies have shown that antibodies against beta-cell antigens can appear after a few months/years of [...]

References:

1.Immunotherapeutic treatment of autoimmune diabetes.
Kim JH, Jin SM, Kim HS, Kim KA, Lee MS
Crit Rev Immunol. 2013;33(3):245-81
2.Type 1 diabetes mellitus and pregnancy
Vargas R, Repke JT, Ural SH.
Rev Obstet Gynecol. 2010 Summer;3(3):92-100
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