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UVC-Induced MAPK Signaling

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UV (Ultraviolet) irradiation is a component of sunlight, which has higher energy than visible light. UV radiation (100 and 400 nm) is divided into at least three different categories based on wavelength: UVA (Ultraviolet-A) , UVB (Ultraviolet-B) and UVC (Ultraviolet-C).  UVC wavelengths (100-280 nm) are very strongly affected by ozone levels, so that the levels of UVC radiation reaching the earth’s surface are relatively small. Because the ozone layer blocks UVC exposure, UVA (UVA I, 340-400 nm; UVA II, 320-340 nm) and UVB (280-320 nm) are probably the chief carcinogenic components of sunlight with relevance for human skin cancer. DNA is known to be an important target for the mutagenic and carcinogenic effects of UV irradiation (Ref.1). In addition to [...]


1.Ultraviolet radiation related exposures: broad-spectrum ultraviolet (UV) radiation, UVA, UVB, UVC, solar radiation, and exposure to sunlamps and sunbeds.
National Toxicology Program.
Rep Carcinog. 2002;10:250-4.
2.Functional genomics of UV radiation responses in human cells.
Koch-Paiz CA, Amundson SA, Bittner ML, Meltzer PS, Fornace AJ Jr.
Mutat Res. 2004 May 18;549(1-2):65-78.
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