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VEGF Family Ligands and Receptor Interactions

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Angiogenesis and lymphangiogenesis, the growth of new blood vessels from preexisting ones, are important processes during embryonic development, tissue growth, wound healing, and several pathological conditions. Several molecules are important for angiogenesis, most important being vascular endothelial growth factor (VEGF) family members and their corresponding receptors. VEGF belongs to the PDGF supergene family characterized by 8 conserved cysteines and functions as a homodimer structure. In mammals, the VEGF family consists of five members: VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor (PIGF). The human VEGF gene (located on chromosome 6) consists of several exons that can be alternatively spliced to encode several protein isoforms including: VEGF121, VEGF145, VEGF162, VEGF165, VEGF183, VEGF189, and VEGF206 (Ref.1 and 2).  VEGFs specifically interact with [...]


1.Structural determinants of growth factor binding and specificity by VEGF receptor 2.
Leppänen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K.
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30. doi: 10.1073/pnas.0914318107.
2.Vascular endothelial growth factor signaling pathways: therapeutic perspective.
Kowanetz M, Ferrara N.
Clin Cancer Res. 2006 Sep 1;12(17):5018-22. Review.
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