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Virus-Induced Airway Inflammation

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Virus-induced cytokine production and inflammatory cell activation are instrumental in the development of neurogenic inflammatory responses, and these combined factors increase bronchoconstriction in response to allergens or irritants. Viral infections can influence both the development and the severity of asthma. In early life, viral infections can either increase or, remarkably, decrease the risk of subsequent asthma. In children and adults with existing asthma, viral respiratory infections frequently cause acute airway obstruction and wheezing.

The airway epithelium is the first cellular component of the lung to be encountered by the particles and pathogens present in inhaled air. Hence it is the focal point in the pathogenesis of viral respiratory infections because it serves as the host cell for viral replication, and [...]


1.Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization.
Arruda E, Boyle TR, Winther B, Pevear DC, Gwaltney JM Jr, Hayden FG.
J Infect Dis. 1995 May; 171(5): 1329-33.
2.Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo.
Grunberg K, Timmers MC, Smits HH, de Klerk EP, Dick EC, Spaan WJ, Hiemstra PS, Sterk PJ.
Clin Exp Allergy. 1997 Jan; 27(1): 36-45.
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