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cAMP Signaling in S. pombe

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The fission yeast S. pombe (Schizosaccharomyces pombe) is homothallic and has a defined sexual cycle involving mating between haploid cells of opposite mating types. In S. pombe, two signaling pathways coordinately regulate mating; the pheromone-activated MAPK (Mitogen-Activated Protein Kinase) signaling and nutrient-regulated, G-protein-cAMP (Cyclic Adenosine 3 ,5 -monophosphate)-PKA (cAMP-Dependent Protein Kinase) pathway (Ref.1). In S. cerevisiae (Saccharomyces cerevisiae), these two signaling pathways have evolved cell type specificity, so that one functions in response to pheromone during Mating and both function to detect nutrients in diploid cells for Filamentous Growth. In contrast, in S. pombe, these two pathways function coordinately in the same cell type to regulate Mating under adverse nutrient conditions and in response to pheromone (Ref.1 & 2). In budding yeast, [...]


1.Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe.
Hoffman CS.
Biochem. Soc. Trans. 2005 Feb;33(Pt 1):257-60.
2.Direct Activation of Fission Yeast Adenylyl Cyclase by Heterotrimeric G Protein gpa2.
Ogihara H, Shima F, Naito K, Asato T, Kariya K, Kataoka T.
Kobe J. Med. Sci. 2004;50(4):111-21.
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