Pathways
Mycothiol metabolism in S. avermitilis
Description:
Soil-inhabiting species of Streptomyces are Gram-positive filamentous bacteria having a complex life cycle that begins with spore germination to form branched multinucleoid vegetative hyphae. The subsequent differentiation process results in formation of erect sporogenic aerial hyphae, followed by chains of unigenomic spores1. During the initiation of morphological differentiation, most Streptomyces species produce bioactive secondary metabolites, including a variety of many important antibiotics with antimicrobial, antitumor...
References:
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SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development.
Sci Rep. 2016 Nov 14;6:36915. doi: 10.1038/srep36915. -
SAV4189, a MarR-Family Regulator in Streptomyces avermitilis, Activates Avermectin Biosynthesis.
Front Microbiol. 2018 Jun 26;9:1358. doi: 10.3389/fmicb.2018.01358. -
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.
Nat Biotechnol. 2003 May;21(5):526-31. doi: 10.1038/nbt820. Epub 2003 Apr 14. -
Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes.
Nat Prod Rep. 2008 Dec;25(6):1091-117. doi: 10.1039/b616489g. Epub 2008 Sep 30.
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