Pathways
IL17 Signaling
Description:
Cytokines are key messenger molecules in cell-to-cell communication and are involved in various aspects of the immune system such as maintaining homeostasis and mediating and resolving pathologic conditions. IL-17 (Interleukin-17) family is a group of cytokines sharing homology in amino acid sequences with highly conserved cysteine residues critical to their 3-dimensional shape. IL-17, the signature cytokine secreted by Th17 cells, is required for host defence against extracellular bacterial and fungal infections, and contrib...
References:
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Signaling of interleukin-17 family cytokines in immunity and inflammation.
Cell Signal. 2011 Jul;23(7):1069-75. -
IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential.
Clin Sci (Lond). 2012 Jun;122(11):487-511. -
IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease.
Trends Immunol. 2011 May; 32(5):232-9. -
Structure and signalling in the IL-17 receptor family.
Nat Rev Immunol. 2009 Aug; 9(8):556-67.
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