Pathways
14-3-3 and Regulation of BAD Activity
Description:
14-3-3 is a phosphoserine/phosphothreonine-binding protein that is being implicated in a wide range of cellular phenomena. 14-3-3 family members are found in all eukaryotes – from plants to mammals – and more than 100 binding partners have been identified to date. They regulate their activities by a number of different mechanisms, which include inter- and intracompartmental sequestration, activation/inactivation of enzymatic activity and promotion/inhibition of protein interactions. The targets of 14-3-3 are found...
References:
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14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.
Semin Cell Dev Biol. 2011 Sep;22(7):688-95. doi: 10.1016/j.semcdb.2011.09.008. Epub 2011 Sep 14. Review. -
The 14-3-3 cancer connection.
Nat Rev Cancer. 2003 Dec;3(12):931-43. Review. No abstract available. -
14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells.
Cell Death Differ. 2016 Jun;23(6):1060-72. doi: 10.1038/cdd.2015.163. Epub 2016 Feb 5. -
14-3-3 proteins in apoptosis.
Braz J Med Biol Res. 2003 Apr;36(4):403-8. Epub 2003 Apr 8. Review.
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