Pathways
14-3-3 in Apoptosis
Description:
14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, formation of ternary complexes and sequestration. They are key regulators of major cellular processes such as proliferation, differentiation, senescence and apoptosis (Ref.1 and 2). Apoptosis is a physiological process of cell death that pl...
References:
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Neuroprotective function of 14-3-3 proteins in neurodegeneration.
Biomed Res Int. 2013;2013:564534. doi: 10.1155/2013/564534. Epub 2013 Dec 2. Review. -
Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character.
Oncogene. 2008 Feb 21;27(9):1315-9. Epub 2007 Aug 20. -
14-3-3 proteins--an update.
Cell Res. 2005 Apr;15(4):228-36. Review. -
14-3-3 proteins in apoptosis.
Braz J Med Biol Res. 2003 Apr;36(4):403-8. Epub 2003 Apr 8. Review.
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