Pathways
14-3-3 Induced Intracellular Signaling
Description:
The 14-3-3 family of proteins consists of molecular adaptors that recognize phosphorylated proteins (e.g. kinases, transcription factors and receptors). They are able to coordinate almost limitless combinations of protein complexes, which accounts for their functional diversity (Ref.1). This plethora of interacting proteins allows 14-3-3 to play important roles in a wide range of vital regulatory processes, such as neuronal development, mitogenic signal transduction, apoptotic cell death, cell cycle control, cell growth contr...
References:
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14-3-3 proteins are essential signalling hubs for beta cell survival.
Diabetologia. 2013 Apr;56(4):825-37. doi: 10.1007/s00125-012-2820-x. Epub 2013 Jan 26. -
Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.
J Biol Chem. 2009 Jan 30;284(5):3183-94. doi: 10.1074/jbc.M804795200. Epub 2008 Dec 2. -
The 14-3-3 proteins in regulation of cellular metabolism.
Semin Cell Dev Biol. 2011 Sep;22(7):713-9. doi: 10.1016/j.semcdb.2011.08.008. Epub 2011 Aug 22. Review. -
Insulin receptor signaling in normal and insulin-resistant states.
Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: a009191. doi: 10.1101/cshperspect.a009191. Review.
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