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14-3-3 Induced Intracellular Signaling


The 14-3-3 family of proteins consists of molecular adaptors that recognize phosphorylated proteins (e.g. kinases, transcription factors and receptors). They are able to coordinate almost limitless combinations of protein complexes, which accounts for their functional diversity (Ref.1). This plethora of interacting proteins allows 14-3-3 to play important roles in a wide range of vital regulatory processes, such as neuronal development, mitogenic signal transduction, apoptotic cell death, cell cycle control, cell growth contr...




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