Pathways
S-1P Stimulated Signaling
Description:
Various lipid molecules serve as second messengers for transducing signals from the cell surface to the cell interior and trigger specific cellular responses. Sphingolipids represent a complex group of lipids that have recently emerged as new transducers in eukaryotic cells. Sphingolipids are found in all mammalian cells and are mostly located in the plasma membrane. They all contain as a backbone a long-chain base – the sphingoid base (mostly sphingosine) – linked to a fatty acid by an amide bond, thus forming ce...
References:
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Roles of sphingosine-1-phosphate signaling in cancer.
Cancer Cell Int. 2019 Nov 14;19:295. doi: 10.1186/s12935-019-1014-8. -
Sphingosine-1-phosphate transporters as targets for cancer therapy.
Biomed Res Int. 2014;2014:651727. doi: 10.1155/2014/651727. Epub 2014 Jul 15. -
Sphingosine 1-phosphate (S1P) signaling in glioblastoma multiforme-A systematic review.
Int J Mol Sci. 2017 Nov 17;18(11):2448. doi: 10.3390/ijms18112448. -
Sphingosine 1-phosphate in metabolic syndrome (Review).
Int J Mol Med. 2016 Oct;38(4):1030-8. doi: 10.3892/ijmm.2016.2731. Epub 2016 Sep 7.
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