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S-1P Stimulated Signaling


Various lipid molecules serve as second messengers for transducing signals from the cell surface to the cell interior and trigger specific cellular responses. Sphingolipids represent a complex group of lipids that have recently emerged as new transducers in eukaryotic cells. Sphingolipids are found in all mammalian cells and are mostly located in the plasma membrane. They all contain as a backbone a long-chain base – the sphingoid base (mostly sphingosine) – linked to a fatty acid by an amide bond, thus forming ce...




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